- Extreme sadness
- Great woe
- Grump
- Intense unhappiness
- Sadness
- Great unhappiness; extreme pain of body or mind;
wretchedness; distress; woe.
- Cause of misery; calamity; misfortune.
- Abandon hope
- Dejection
- Give up all hope
- Give up hope
- Gloom
- Great woe
- Have no hope of changing diapers