- No matter, ... of - Regardless - Without regard for conditions, circumstances, or
consequences; unbiased; independent; impartial; as, an irrespective
judgment. - Disrespectful.
- In the face of - Notwithstanding - Regardless of - Malice; malignity; spite; malicious anger; contemptuous
hate. - An act of malice, hatred, or defiance; contemptuous
defiance; a deed of contempt. - To vex; to annoy; to offend contemptuously. - In spite of; against, or in defiance of;
notwithstanding; as, despite his prejudices.