- Extreme sadness - Great woe - Grump - Intense unhappiness - Sadness - Great unhappiness; extreme pain of body or mind;
wretchedness; distress; woe. - Cause of misery; calamity; misfortune.
- Cause trouble to - Distress greatly - Physically harmful - Trouble grievously - To strike or cast down; to overthrow. - To inflict some great injury or hurt upon, causing
continued pain or mental distress; to trouble grievously; to torment. - To make low or humble.