- Asininely
- Blindly
- Futilely
- needlessly
- Pointlessly
- Despondently
- Futilely
- Irredeemably
- Futilely
- Getting inside blood vessel, they say, will be to no avail
- pointlessly
- To no avail
- With no success
- Without success
- Futilely
- To no avail, describes how a bun with no currants is made